Every piece links its primary source at the top and answers one question: what changes for a plant.
Updated 45 pieces 6 field reports 245 primary sources read for them
Field Reports
One question per report: what the papers, regulators and company data say, what holds up, and what a plant should do about it.
FR-06 · 40 sources
Scale-Up & CapacityField report
We read 40 primary sources on bioreactor scale-up. No criterion can be held with the others; in cell culture the trouble is usually CO2 and the sparger, in microbial fermentation oxygen and heat, and kLa correlations do not travel between scales.
FR-05 · 43 sources
Bioprocess 4.0Field report
We read 43 primary sources. Raman tracks glucose well and titre poorly, capacitance counts cells until they stop growing and swell, models break when the cell line, scale or probe changes, and no regulator requires any of it.
FR-04 · 46 sources
Scale-Up & CapacityField report
We read 46 primary sources. ATF and TFF use the same hollow fibre and differ in the pump. Both hold back product as the filter ages, the head-to-head studies disagree, and what fouls the fibre is particles the size of its pores.
FR-03 · 40 sources
Scale-Up & CapacityField report
We read 40 primary sources. Perfusion makes several times more per litre per day and, in three models, needs five to eight times less bioreactor volume, but in the cost models read in full it only wins at small scale.
FR-02 · 38 sources
Scale-Up & CapacityField report
We read 38 primary sources on CHO perfusion. Two flows deserve most of the attention on cost: the medium you buy and the product the bleed throws away.
FR-01 · 38 sources
Scale-Up & CapacityField report
We read 38 primary sources on CHO scale-up. The trouble at 2,000 L is on the gas side and at harvest, not in impeller eddies.
News
Bioprocess 4.0Brief
A*STAR researchers ran Lactococcus lactis in perfusion with tangential flow filtration and used a process model to trade secreted FGF2 titer against media use.
Bioprocess 4.0Brief
Bioprocess 4.0Brief
Precision FermentationBrief
Bioprocess 4.0Brief
Bioprocess 4.0Brief
Scale-Up & CapacityBrief
Southern Europe RadarRadar
Precision FermentationBrief
Scale-Up & CapacityBrief
Bioprocess 4.0Brief
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Field reportBioreactor scale-up, explained: P/V, tip speed, kLa, vvm and mixing time, and why none of them holds on its own
Field reportPAT in practice: which bioprocess sensors and models hold up, where they break, and where to startEditorial coverage from primary sources. No company on this list paid to appear. See Interests.
USP and DSP scale-up, new plants, CDMO capacity, reshoring and the policy behind it.
PAT, automation, AI, digital twins, process data and how to validate them.
Industrial scale-up, capacity and economics of precision and biomass fermentation.
Biomanufacturing and pharma manufacturing moves in Spain, Portugal and Italy.