Every piece links its primary source at the top and answers one question: what changes for a plant.
Updated 54 pieces 7 field reports 290 primary sources read for them
Field Reports
One question per report: what the papers, regulators and company data say, what holds up, and what a plant should do about it.
FR-07 · 45 sources
Bioprocess 4.0Field report
We read 45 primary sources on AI in bioprocessing. In GMP today: narrow soft sensors and multivariate monitoring. Closed-loop control, predictive twins and language models are lab, development or claims, and the EU Annex 22 on AI is still a draft.
FR-06 · 40 sources
Scale-Up & CapacityField report
We read 40 primary sources on bioreactor scale-up. No criterion can be held with the others; in cell culture the trouble is usually CO2 and the sparger, in microbial fermentation oxygen and heat, and kLa correlations do not travel between scales.
FR-05 · 43 sources
Bioprocess 4.0Field report
We read 43 primary sources. Raman tracks glucose well and titre poorly, capacitance counts cells until they stop growing and swell, models break when the cell line, scale or probe changes, and no regulator requires any of it.
FR-04 · 46 sources
Scale-Up & CapacityField report
We read 46 primary sources. ATF and TFF use the same hollow fibre and differ in the pump. Both hold back product as the filter ages, the head-to-head studies disagree, and what fouls the fibre is particles the size of its pores.
FR-03 · 40 sources
Scale-Up & CapacityField report
We read 40 primary sources. Perfusion makes several times more per litre per day and, in three models, needs five to eight times less bioreactor volume, but in the cost models read in full it only wins at small scale.
FR-02 · 38 sources
Scale-Up & CapacityField report
We read 38 primary sources on CHO perfusion. Two flows deserve most of the attention on cost: the medium you buy and the product the bleed throws away.
FR-01 · 38 sources
Scale-Up & CapacityField report
We read 38 primary sources on CHO scale-up. The trouble at 2,000 L is on the gas side and at harvest, not in impeller eddies.
News
Bioprocess 4.0Brief
A J. Agric. Food Chem. paper extracts chitin from shrimp shell by lactic acid fermentation on coconut water plus a protease step, and repeats it in a stirred-tank bioreactor.
Bioprocess 4.0Brief
Bioprocess 4.0Brief
Bioprocess 4.0Brief
Bioprocess 4.0Brief
Bioprocess 4.0Brief
Bioprocess 4.0Brief
Bioprocess 4.0Brief
Bioprocess 4.0Brief
Bioprocess 4.0Brief
Bioprocess 4.0Brief
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Field reportAI in bioprocessing, explained: what actually runs in a plant, what does not, and how it is validated
Field reportBioreactor scale-up, explained: P/V, tip speed, kLa, vvm and mixing time, and why none of them holds on its ownEditorial coverage from primary sources. No company on this list paid to appear. See Interests.
USP and DSP scale-up, new plants, CDMO capacity, reshoring and the policy behind it.
PAT, automation, AI, digital twins, process data and how to validate them.
Industrial scale-up, capacity and economics of precision and biomass fermentation.
Biomanufacturing and pharma manufacturing moves in Spain, Portugal and Italy.