Every piece links its primary source at the top and answers one question: what changes for a plant.
Updated 59 pieces 8 field reports 291 primary sources read for them
Field Reports
One question per report: what the papers, regulators and company data say, what holds up, and what a plant should do about it.
FR-08
Bioprocess 4.0Field report
A preprint reports needing 2.5 to 7.1 times fewer designs to engineer a production strain with machine learning. We read it in full plus 40 other primary sources. The saving is in simulated designs: no strain was built. What machine learning has done with real lab data, and where the models break.
FR-07 · 46 sources
Bioprocess 4.0Field report
We read 46 primary sources on AI in bioprocessing. In GMP today: narrow soft sensors and multivariate monitoring. Closed-loop control, predictive twins and language models are lab, development or claims, and the EU Annex 22 on AI is still a draft.
FR-06 · 40 sources
Scale-Up & CapacityField report
We read 40 primary sources on bioreactor scale-up. No criterion can be held with the others; in cell culture the trouble is usually CO2 and the sparger, in microbial fermentation oxygen and heat, and kLa correlations do not travel between scales.
FR-05 · 43 sources
Bioprocess 4.0Field report
We read 43 primary sources. Raman tracks glucose well and titre poorly, capacitance counts cells until they stop growing and swell, models break when the cell line, scale or probe changes, and no regulator requires any of it.
FR-04 · 46 sources
Scale-Up & CapacityField report
We read 46 primary sources. ATF and TFF use the same hollow fibre and differ in the pump. Both hold back product as the filter ages, the head-to-head studies disagree, and what fouls the fibre is particles the size of its pores.
FR-03 · 40 sources
Scale-Up & CapacityField report
We read 40 primary sources. Perfusion makes several times more per litre per day and, in three models, needs five to eight times less bioreactor volume, but in the cost models read in full it only wins at small scale.
FR-02 · 38 sources
Scale-Up & CapacityField report
We read 38 primary sources on CHO perfusion. Two flows deserve most of the attention on cost: the medium you buy and the product the bleed throws away.
News
Bioprocess 4.0Brief
over 99%
Reduction in host cell DNA in the monoclonal antibody culture fluid after flocculation with the best of five cationic polymers tested (Biotechnology Progress, 2 Nov 2026)
A BOKU University study screened five cationic flocculants on mAb cell culture fluid. The best one cut host cell DNA by over 99% and total host cell proteins by up to 40%.
Bioprocess 4.0Brief
Precision FermentationBrief
Scale-Up & CapacityBrief
Bioprocess 4.0Brief
Bioprocess 4.0Brief
Bioprocess 4.0Brief
Bioprocess 4.0Brief
Bioprocess 4.0Brief
Bioprocess 4.0Brief
Bioprocess 4.0Brief
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Field reportMachine learning strain design, explained: what ML4SD does, and what has actually been proven
Field reportAI in bioprocessing, explained: what actually runs in a plant, what does not, and how it is validatedEditorial coverage from primary sources. No company on this list paid to appear. See Interests.
USP and DSP scale-up, new plants, CDMO capacity, reshoring and the policy behind it.
PAT, automation, AI, digital twins, process data and how to validate them.
Industrial scale-up, capacity and economics of precision and biomass fermentation.
Biomanufacturing and pharma manufacturing moves in Spain, Portugal and Italy.