👨🔬 The use of vertical bioreactors allows for higher cell densities and better oxygen delivery.
🚀 The combination of vertical bioreactors and microcarriers enables the growth of certain cell types.
🐎 The study focused on equine cell therapy, but the technology can be applied to human cell therapies.
⚙️ Cell therapy producers will need a variety of bioreactors as production processes continue to evolve.
Introduction:
Vertical bioreactors could be a beneficial technology for the cell therapy sector, according to a new study. The use of vertical bioreactors allows for higher cell densities in culture compared to traditional stirred tank reactors, making them more suited for cell therapy manufacturing. The study used vertical bioreactors in combination with microcarriers to culture mesenchymal stromal cells derived from equine cord blood.
- Vertical bioreactors offer higher cell densities in culture compared to traditional stirred tank reactors.
- Stirred tank reactors have high shear forces that can damage cells.
- Vertical bioreactors in combination with microcarriers provide a large surface area for cell growth while minimizing shear forces.
- The technology described in the study can be used for the production of human cell therapies.
- Cell therapy producers will need a range of bioreactor types to accommodate different production processes.
Conclusion:
Vertical bioreactors, particularly in combination with microcarriers, have the potential to revolutionize the cell therapy sector. They offer higher cell densities and a reduced risk of damage to cells compared to traditional stirred tank reactors. The use of bioreactors, including both vertical and traditional systems, will be necessary to support the production processes of different types of cell therapies. This technology has the potential to improve the scalability, cost-effectiveness, and quality of cell therapies. Further research and development in this area will be important for advancing the field of regenerative medicine.
