BIOT 
The CGT CDMO now runs cell therapies, viral vectors and advanced testing as three business units. Viral vector CDMO services are centralized at its Philadelphia site.
Abionyx Pharma and CDMO Olon sign a manufacturing deal for CER-001, covering upstream production, phospholipid complexation and fill and finish across two French sites.
We read 43 primary sources. Raman tracks glucose well and titre poorly, capacitance counts cells until they stop growing and swell, models break when the cell line, scale or probe changes, and no regulator requires any of it.
We read 46 primary sources. ATF and TFF use the same hollow fibre and differ in the pump. Both hold back product as the filter ages, the head-to-head studies disagree, and what fouls the fibre is particles the size of its pores.
Engineered Yarrowia lipolytica secretes human lactoferrin at 409.9 mg/L in shake flasks and 3.14 g/L in an optimized 5 L fed-batch run.
We read 40 primary sources. Perfusion makes several times more per litre per day and, in three models, needs five to eight times less bioreactor volume, but in the cost models read in full it only wins at small scale.
A McGill preprint encapsulates stem-cell-derived islets in alginate beads to stop clumping in 25-day bioreactor culture, with 91% cell recovery vs 60% without.
Pfizer reports scaling its HILVOP dynamic perfusion process to 500 L, with TFF membrane fouling as a key scale-up risk.
Cornell, Harvard and Utrecht researchers grow kidney ureteric bud and collecting duct organoids on ECM microcarriers in stirred bioreactors, per a new preprint.
A bioRxiv preprint on simulated penicillin batches shows adding deviation batches to soft-sensor training cuts deviation-batch RMSE 19.7% without hurting normal-run accuracy.