A Biotechnology and Bioengineering paper describes a digital twin that times the N-1 seed transfer for a commercial antibody process. Only the abstract was available.
A Microbial Cell Factories study uses a temperature-sensitive RNA element instead of a chemical inducer to switch on protein production in E. coli, and tracks where the carbon goes.
A Bioprocess and Biosystems Engineering paper compares four CHO fed-batch feeding strategies for an IgG1 antibody. The full strategy reports lower lactate and ammonia and a higher titre.
A Biotechnology Progress paper reports that a linear 70% methanol, 30% glycerol feed doubled HPV16 L1 VLP titer in a microbioreactor and held at 1 L scale.
The CGT CDMO now runs cell therapies, viral vectors and advanced testing as three business units. Viral vector CDMO services are centralized at its Philadelphia site.
Abionyx Pharma and CDMO Olon sign a manufacturing deal for CER-001, covering upstream production, phospholipid complexation and fill and finish across two French sites.
We read 43 primary sources. Raman tracks glucose well and titre poorly, capacitance counts cells until they stop growing and swell, models break when the cell line, scale or probe changes, and no regulator requires any of it.
We read 46 primary sources. ATF and TFF use the same hollow fibre and differ in the pump. Both hold back product as the filter ages, the head-to-head studies disagree, and what fouls the fibre is particles the size of its pores.
Engineered Yarrowia lipolytica secretes human lactoferrin at 409.9 mg/L in shake flasks and 3.14 g/L in an optimized 5 L fed-batch run.
We read 40 primary sources. Perfusion makes several times more per litre per day and, in three models, needs five to eight times less bioreactor volume, but in the cost models read in full it only wins at small scale.