A Biotechnology and Bioengineering study tests a monoclonal antibody polishing block run at about pH 5.0 after mild-pH Protein A elution, with no pH adjustment between steps.
A Bioprocess and Biosystems Engineering paper compares four CHO fed-batch feeding strategies for an IgG1 antibody. The full strategy reports lower lactate and ammonia and a higher titre.
A Biotechnology Progress paper reports that a linear 70% methanol, 30% glycerol feed doubled HPV16 L1 VLP titer in a microbioreactor and held at 1 L scale.
Engineered Yarrowia lipolytica secretes human lactoferrin at 409.9 mg/L in shake flasks and 3.14 g/L in an optimized 5 L fed-batch run.
Pfizer reports scaling its HILVOP dynamic perfusion process to 500 L, with TFF membrane fouling as a key scale-up risk.
Lund University recycled Protein A equilibration buffer and CIP buffer in mAb purification. How the scheme works, what it saved, and what a GMP plant would still need to prove.
Pow.Bio and Bühler sell a continuous fermentation platform after a 3,000 L run at ATV. What the releases claim, what they leave out, and the strain-stability risk to check.
A reported 7 to 8 hour half-life at 37 degrees C shapes the process. Four open-access papers on perfusion, retention devices and adherent scale-up, with the numbers.
Sanofi built the prototypes, Sartorius got exclusive rights to sell the platform. What the 2024 release says, what it leaves out, and what ICH Q13 asks a plant to prove.