🔧 New TFF technology optimizes downstream processes. TangenX SC offers a holder-less design, reducing contamination and complexity.
💨 This innovative approach enhances speed and efficiency in mAb production. It supports both single-use and multi-use workflows, ensuring consistent quality.
🚀 Embracing this tech can accelerate the production of vital therapeutics.
Introduction:
The article discusses the challenges faced in the downstream manufacturing of therapeutic monoclonal antibodies (mAbs) and introduces a new tangential flow filtration (TFF) technology that aims to alleviate these bottlenecks. It highlights the shift from traditional stainless steel TFF systems to innovative, holder-less devices designed to enhance efficiency and reduce contamination risks in biopharmaceutical production.
- Traditional batch-based manufacturing of mAbs is evolving due to increasing biopharmaceutical demands, necessitating advancements in downstream processing technologies.
- Conventional TFF systems are complex and prone to operator error, leading to inefficiencies and contamination risks during mAb production.
- The introduction of holder-less, self-contained TFF devices, such as Repligen’s TangenX SC, simplifies workflow and reduces process setup time.
- TangenX SC provides high recovery rates and reliability across multiple reuse cycles, with validated cleaning protocols ensuring consistency and regulatory compliance.
- The adoption of this innovative TFF design supports biopharmaceutical companies in achieving scalable processes that enhance product quality and speed to market.
Conclusion:
The article emphasizes the necessity for the biopharmaceutical industry to transition to advanced TFF systems like TangenX SC, which offer significant improvements in efficiency, ease of use, and consistency for mAb manufacturing. This shift is crucial for meeting growing market demands and ensuring that therapeutic innovations reach patients faster and with enhanced quality. Future directions in biomanufacturing will likely continue to favor closed and continuous systems to further minimize manual handling and operational complexities.
