calibration models
calibration models
Revolutionizing Bioprocessing: Metabolism Enhances Accuracy
📰 Adding metabolism to bioprocessing models improves accuracy & value. Multiscale models provide a mechanistic understanding for better control. 🧪🔬
Revolutionary Model Predicts Biologic Processing Variations
🔍 Scientists have developed a mathematical model to predict RTD in continuous manufacturing of biologics. 🔬🔬🧪💯🔬
Time-saving Raman Spectroscopy Models for Cell Culture Monitoring
🔍 Raman spectroscopy is becoming popular for monitoring cell cultures in biopharmaceutical production. 🔬 Creating accurate calibration models for Raman-based monitoring is challenging and time-consuming. 🧪 Scientists developed orthogonal projection to latent structures (OPLS) models to predict production and culture indicators. 📊 The models accurately predicted glucose and lactate levels across different clones, but had issues with predicting titer levels. ✨ A generic calibration model can be used for glucose and lactate levels, but not for product prediction. 🔬 Raman spectroscopy is useful for monitoring cell cultures, but creating calibration models is still time-consuming.
