🧫 These bioinks can be used for cellular interactions in 3D and in vivo implantation.
🩹 Three hydrogels were developed, with the DT-gel being the most promising for cartilage regeneration.
💡 The D-gel has potential for wound healing and cancer cell metastasis research.
🔬 The T-gel supports cell proliferation and stability.
🔎 The hydrogels showed stability in a buffer environment and increased expressions of stemness markers.
🌱 Future research aims to explore the chondrogenic properties of the hydrogels for cartilage regeneration and tissue model construction.
Introduction:
Researchers have made advancements in bioinks for regenerative medicine by combining dynamic and nondynamic linkages. These bioinks can be used for 3D cellular interactions and in vivo implantation. The scientists developed three hydrogels, each using different crosslinking mechanisms, to optimize the performance and functionality of bioinks. The DT-gel, which combines disulfide and thiazolidine linkages, is considered the most promising candidate for bioink applications, particularly for cartilage regeneration. The D-gel and T-gel also have specific attributes that make them suitable for understanding physiological activities and cancer research, respectively.
- Combining dynamic and nondynamic linkages in bioink has improved its performance and functionality.
- The DT-gel, which uses both disulfide and thiazolidine linkages, is the most promising candidate for bioink applications.
- The D-gel is valuable for understanding physiological activities, while the T-gel holds potential for cancer research.
- Stability of the hydrogels depends on the interplay between disulfide and thiazolidine linkages.
- Future research will focus on exploring the chondrogenic properties of the hydrogels and constructing complex tissue models to simulate interactions between cell types.
Conclusion:
By combining dynamic and nondynamic linkages, researchers have developed bioinks with improved performance and functionality. The DT-gel, in particular, shows promise for cartilage regeneration. These advancements in bioinks can facilitate 3D cellular interactions and in vivo implantation. Future research will explore the potential applications of the hydrogels and their interactions with different cell types, including cancer and immune cells.
