Introduction:
Researchers have discovered a potential target for atherosclerosis, a chronic disease that affects the vascular wall and leads to complications such as heart attacks and strokes. The receptor TREM2, found on the surface of macrophages, has been found to reduce necrotic core formation in early atherosclerosis, which is a key factor in plaque formation.
- TREM2 deficiency increases necrotic core formation in early atherosclerosis, while TREM2 agonism decreases it.
- TREM2 is essential for the clearance of dead cells by macrophages and the survival of lipid-laden macrophages.
- An agonistic TREM2 antibody called 4D9 reduced the formation of necrotic cores in atherosclerotic plaques in mice.
- Soluble TREM2 in the blood correlated with the growth of plaques in the carotid artery of patients.
- TREM2 could be diagnostically and therapeutically useful in atherosclerosis prevention and treatment.
Conclusion:
The discovery of the potential role of TREM2 in atherosclerosis could have significant implications for preventing and treating the disease. By targeting TREM2, researchers may be able to reduce necrotic core formation and improve the stability of atherosclerotic plaques, thereby reducing the risk of complications such as heart attacks and strokes. Further research is needed to fully understand the diagnostic and therapeutic potential of TREM2 in atherosclerosis.
