🔬 Intensified fed-batch processing offers a solution. It boosts productivity five to ten times and lowers costs.
📈 This approach involves fixed-volume feeding strategies, simplifying operations while increasing yields from 7 g/L to 18 g/L.
⚡ Challenges include nutrient balance and culturing demands, but innovations in feed formulations help improve outcomes.
🚀 This method signals a transformative change in bioprocessing, enabling faster market access.
Introduction:
This article discusses the innovative approach of intensified fed-batch processing in biologics manufacturing, highlighting its potential to enhance productivity while addressing the industry’s dual challenges of increasing demand and the need for cost reduction. The insights were primarily shared by Dr. Yuxin Liu at the Bioprocess International Conference in Boston.
- Intensified fed-batch processing enhances productivity significantly, yielding five to ten times more product compared to conventional fed-batch methods.
- The method integrates perfusion with streamlined feeding strategies, resulting in simpler operations and reduced variability across production runs.
- Recent advancements have shown titers increase from 7 g/L to 18 g/L in just 14 days, due to fixed-volume feeding strategies that eliminate the need for daily adjustments.
- Although promising, the method faces challenges including precise media formulation to support high-density cultures and issues of lactate buildup and nutrient depletion.
- Improvements in feed formulations and a reduction in operational complexity enhance quality assurance and efficiency, marking a significant shift in upstream bioprocessing.
Conclusion:
The ongoing development of intensified fed-batch processing represents a paradigm shift in biologics manufacturing, offering increased efficacy and reduced costs. As the industry continues to refine this method, it stands to significantly improve production timelines and support accelerated access to market for new biologic therapies, ultimately benefiting patient outcomes.
