Introduction:
This article discusses the use of microbial systems in bioprocessing and the development of a new cell line, PUREcoli, by KBI Biopharma. The PUREcoli cell line has undergone extensive genetic engineering, resulting in improved protein expression and faster growth rates compared to common E. coli strains. This advancement in microbial manufacturing has the potential to enhance the efficiency and effectiveness of bioprocessing.
- KBI Biopharma has developed the PUREcoli cell line, which has been genetically engineered to improve microbial manufacturing in bioprocessing.
- The genome of the PUREcoli cell line has been streamlined by eliminating unnecessary genes and reducing modifications, resulting in faster growth rates and higher cell density.
- The PUREcoli cell line has shown promise in the expression of troublesome proteins, overcoming challenges faced by E. coli-based methods.
- Researchers are continuously looking for new cell lines and genetic modifications to optimize bioprocessing and enhance protein expression.
- Other microbial systems, such as engineered Vibrio natriegens, are also being explored as low-cost and scalable platforms for synthetic biological experiments.
Conclusion:
The development of the PUREcoli cell line represents a significant advancement in microbial manufacturing for bioprocessing. By streamlining the genome and optimizing protein expression, this cell line offers improved efficiency and the potential for higher yields in protein production. Continued research and development in microbial systems and genetic engineering will contribute to further advancements in bioprocessing and protein expression.
