📌 This system is advantageous for bioprocessing upstream, including culturing of animal or microbial cells.
📌 The system uses controlled feeding, aerating, and process strategies in different vessel types.
📌 It also provides options for assays, bioreactors, cell culture media, and expression platforms, among others.
📌 Downstream processing involves removing contaminants through centrifugation, filtration, and chromatographic technologies.
📌 The XCell® ATF system offers advantages in downstream processing, such as filtration, separation/purification, and viral clearance.
📌 The system is also beneficial for manufacturing drug products, including biosimilars and cell/gene therapies.
📌 Analytical technologies are used to characterize biological products, manufacturing processes, and raw materials.
📌 The XCell® ATF system supports analytical applications for culture development, cell line development, and product characterization.
📌 The system is advantageous for businesses in the biopharmaceutical industry, providing support for careers, economics, and regulatory affairs.
⚡️ In summary, the XCell® ATF system offers productivity and scalability benefits for bioprocessing, including upstream and downstream processing, manufacturing, analytical applications, and business support.
Introduction:
This article highlights the advantages of using the XCell® ATF System for upstream process intensification in the biotechnology industry. The XCell® ATF System is a filtration technology that offers unmatched productivity and seamless scalability.
- The XCell® ATF System allows for continuous cell retention during cell culture processes, resulting in significantly higher product yields compared to traditional batch processes.
- The system provides consistent and controlled perfusion rates, maintaining optimal conditions for cell growth and productivity throughout the entire culture period.
- With improved cell retention, the XCell® ATF System enables higher cell densities, leading to increased productivity and reduced process times.
- The system’s scalability allows for easy adaptation to different production scales, from small-scale research and development to large-scale manufacturing.
- By eliminating the need for centrifugation or other cell separation methods, the XCell® ATF System simplifies the downstream processing and reduces the overall process complexity.
Conclusion:
The XCell® ATF System offers several advantages for upstream process intensification in the biotechnology industry. Its continuous cell retention, controlled perfusion rates, scalability, and simplified downstream processing contribute to increased productivity and efficiency. Incorporating this filtration technology can significantly improve the productivity and scalability of upstream processes, leading to more efficient and cost-effective biomanufacturing.
