🧪 Traditional electrochemical sensors are accurate but may lose accuracy as cells age.
🌟 Optical sensors, on the other hand, are less accurate but offer convenience in single-use bioprocessing.
💡 It is important to consider the limitations of these sensors and incorporate them into process control to avoid fluctuations in product quality.
📊 A recent study compared the performance of electrochemical and optical sensors in various bioreactors.
🔬 The results showed that optical pH sensors tend to be less accurate than electrochemical ones.
👩🔬 Researchers recommended using single-use pH sensors in upstream bioprocessing but with proper process control.
Introduction:
pH monitoring is crucial in bioprocessing to ensure cell survival and maintain product quality. Traditional methods of measuring pH in bioreactors involve electrochemical probes, but optical sensors are also being used. A recent study compared the accuracy and performance of electrochemical and optical pH sensors in different bioreactors.
- The study compared electrochemical and optical pH sensors in upstream bioprocessing.
- Electrochemical sensors were found to be more accurate than optical sensors, but became less accurate as cells aged.
- The results suggest that single-use pH sensors can be used in upstream bioprocessing, but their limitations should be taken into account.
Conclusion:
The study found that both electrochemical and optical pH sensors have their advantages and limitations. While electrochemical sensors are more accurate overall, they may lose accuracy over time. On the other hand, optical sensors are less accurate but offer the convenience of single-use. These findings highlight the need to consider the specific requirements of the bioprocessing system when choosing pH sensors for upstream bioprocessing.
