🔬 Their synthetic biology approach uses genetic plugins to prevent cells from “micro-evolving,” which diminishes monoclonal antibody (mAb) production.
📈 This technology enhances high-producing cell composition, improving outcomes over time.
🤝 Enduro is now networking with others in the industry to expand its innovative solutions.
Introduction:
The article discusses a novel approach developed by Enduro Genetics to enhance the production of monoclonal antibodies (mAbs) through the application of synthetic biology. By employing genetic plugins that utilize biosensors and promoters, the company aims to counteract micro-evolutionary tendencies in manufacturing cells, thereby increasing productivity in industrial bioprocesses.
- Enduro Genetics has created genetic plugins that employ biosensors and burden-responsive promoters to detect and regulate mAb production levels in cells.
- The technology reorganizes the cell population to favor higher-producing cells, thus increasing the overall yield of mAbs.
- This synthetic biology approach incentivizes cells to enhance their productivity by making it evolutionarily advantageous for them to do so.
- Enduro Genetics is distinctive in this approach, having secured patent protection since their establishment in 2014.
- The company is engaging with industry stakeholders at events like the Bioprocessing Summit Europe to facilitate discussions on adaptive evolution in bioprocessing environments.
Conclusion:
Enduro Genetics’ innovative strategies represent a significant advancement in the field of bioprocessing, addressing the challenges of cell differentiation during mAb production. As the company continues to collaborate with industry leaders, it could pave the way for improved manufacturing processes that maximize cellular output and efficiency, signalling a shift in how synthetic biology can be leveraged in commercial applications.
