Introduction:
This article discusses the importance of analytics in the manufacturing of autonomous vehicles (AV) and autonomous aerial vehicles (AAV). The production of safe and effective medicines in the biomanufacturing industry relies on controlled and well-characterized processes, and the same principles apply to AV and AAV manufacturing. The main challenge in viral vector manufacturing is to develop robust processing steps supported by rapid and reliable analytical methods.
- Viral vector manufacturing faces the challenge of developing robust processing steps supported by analytical methods.
- Consistent product quality is crucial in ensuring the success of any virus production process.
- Switching from adherent-cell platforms to suspension-cell platforms requires a comprehensive comparability study.
- Process development and analytical support are essential for scaling up AV and AAV production.
- Empty capsids pose a challenge in downstream processing and require effective removal methods.
Conclusion:
Analytics play a critical role in the manufacturing of AV and AAV, ensuring consistent product quality and supporting scale-up processes. Robust analytical methods are needed to quantify capsid titers, genome quantities, and impurities. Process analytic technology (PAT) implementations are slowly advancing in AAV manufacturing. Effective removal of empty capsids is a major challenge, but techniques for their removal are being developed. Overall, the integration of analytics is key to the success and efficiency of AV and AAV manufacturing processes.
