A reported 7 to 8 hour half-life at 37 degrees C shapes the process. Four open-access papers on perfusion, retention devices and adherent scale-up, with the numbers.
Sanofi built the prototypes, Sartorius got exclusive rights to sell the platform. What the 2024 release says, what it leaves out, and what ICH Q13 asks a plant to prove.
Researchers report dropping the endonuclease step in AAV lysate clarification. What the authors’ abstract and the filter maker’s data show, and what a plant would still need to prove.